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KMID : 0370220230670010001
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Yakhak Hoeji
2023 Volume.67 No. 1 p.1 ~ p.7
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Immunomodulatory Role of Neuropeptide Y in Intestinal Inflammation
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Lee Yun-Na
Im Eun-Ok
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Abstract
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Neuropeptide Y (NPY) is a 36-amino acid peptide found in the brain, autonomic nervous system, and differentperipheral tissues, including the gastrointestinal (GI) tract. Dysfunction of the NPY or NPY system has been implicatedin various tumor microenvironments and cardiovascular and GI disorders, such as inflammatory bowel disease (IBD). IBD,including Crohn’s disease (CD) and ulcerative colitis (UC), is a major health concern due to its increasing incidenceglobally. Emerging evidence has demonstrated that NPY also acts as a potent immunomodulator by linking the nervousand immune systems. NPY plays an important role in immunopathology during intestinal inflammation. This paperdiscusses the potential role of NPY as a valuable biomarker for IBD due to its consistent upregulation in both in vivo andclinical studies. Consequently, it confirms the pro-inflammatory effects of NPY, providing a rational basis for targetingNPY signaling as a therapeutic strategy.
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KEYWORD
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Neuropeptide Y, Intestinal inflammation, IBD, Immune modulator
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